About this raise
Cytonics, with a valuation of $104.08 million, is raising funds on StartEngine through Reg A+ crowdfunding. The company is a leader in regenerative medicine and has developed innovative therapies for musculoskeletal diseases like osteoarthritis. Cytonics has created an Autologous Platelet Integrated Concentration system concentrating A2M from patients’ blood to treat their own damaged joints. The company has a strong IP portfolio with 24 US and international patents issued, and it has treated over 10,000 patients to date. Gaetano Scuderi founded Cytonics in July 2006. The current crowdfunding campaign has a maximum target of $24.7 million. The campaign proceeds will be used for the phase 2 clinical study, GMP drug production, and working capital.
Investment Overview
Committed $2,461,864 :
Deal Terms
Company & Team
Company
- Year Founded
- 2006
- Industry
- Healthcare & Pharmaceuticals
- Tech Sector
- Distribution Model
- B2B2C
- Margin
- Medium
- Capital Intensity
- High
Financials
- Revenue -59.3% YoY
- $170,002
- Monthly Burn
- $213,667
-
Runway
- 10.3 months
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Synopsis
Cytonics is a U.S.-based biotechnology company pioneering new treatments for osteoarthritis (OA). Founded in 2006 by orthopedic surgeon Dr. Gaetano Scuderi, Cytonics began with a focus on understanding the molecular causes of joint pain. Early on, the company developed a diagnostic test (the Fibronectin-Aggrecan Complex Test, or FACT™) to detect biomarkers of cartilage damage in joint fluid. This research led to a breakthrough discovery: a naturally occurring blood protein called alpha-2-macroglobulin (A2M) can halt the cartilage breakdown that drives osteoarthritis. Building on this insight, Cytonics created the Autologous Platelet Integrated Concentration (APIC™) system – a medical device that concentrates A2M from a patient’s own blood and injects it into the affected joint. APIC is unique in delivering high doses of A2M directly to the joint, aiming to reduce pain and slow or stop osteoarthritis progression. Over the past decade, more than ten thousand patients have received APIC treatments (even elite racehorses have benefited), providing real-world evidence of its potential. Cytonics holds multiple patents on these technologies, and even licensed its FACT diagnostic to a Johnson & Johnson subsidiary (Synthes) in 2011, underscoring the industry’s recognition of its innovation.
Today, Cytonics is advancing a next-generation OA therapy called CYT-108. CYT-108 is a laboratory-engineered variant of the A2M protein, designed to be even more potent and longer-lasting than the natural version. Importantly, CYT-108 would be an “off-the-shelf” injectable drug – meaning patients could receive the treatment from a prepared vial, without needing their blood drawn and processed. This could make A2M therapy far more accessible and scalable if approved. CYT-108 has shown encouraging results in animal studies, and Cytonics recently completed a first-in-human Phase 1 clinical trial, establishing initial safety. The company is now preparing for a Phase 2 trial to evaluate efficacy in patients with knee osteoarthritis.
Price
Cytonics is offering Common Equity in its current funding round, with a pre-money valuation of $104.08 million and a price per share set at $3.00. Common equity provides investors with ownership stakes and voting rights, but ranks below preferred equity in terms of dividend and liquidation preferences. This means that in the event of liquidation, common shareholders are compensated after preferred shareholders.
For investors considering Cytonics, the potential for exit returns is an important factor. To achieve a 10X return, Cytonics would need to reach a post-exit valuation of approximately $1.04 billion. This calculation does not account for dilution, which could affect returns. Achieving such a valuation would likely require significant advancements in product development, successful clinical trials, and substantial market penetration in the osteoarthritis therapeutics market.
Market
Osteoarthritis is often called the “wear-and-tear” arthritis, and it is extremely prevalent. In the United States alone, over 30 million adults have some form of OA today, and that number is steadily rising with the aging population and obesity rates. By 2030, it’s projected that around 67 million Americans will have doctor-diagnosed arthritis, with OA being the most common type. This creates a vast and growing market for any effective treatment. Focusing specifically on osteoarthritis treatments, the U.S. osteoarthritis therapeutics market is valued at around $9-10 billion annually in the mid-2020s. Within that, a significant segment is injectable therapies for OA, such as corticosteroid injections and viscosupplementation (hyaluronic acid gel shots). A recent analysis pegged the U.S. OA injectables market at about $4 billion in 2023, with an expected growth rate of roughly 6-7% per year. That means by 2030, the U.S. could be spending over $6 billion each year just on injections for osteoarthritic joints. Globally, the OA treatment market is even larger – estimates suggest it could reach around $11 billion in 2025 and continue growing as populations age.
Despite the billions spent, current osteoarthritis treatments are largely palliative, addressing symptoms rather than the underlying disease. Patients typically cycle through pain relievers (like NSAIDs), physical therapy, and injections (steroids to reduce inflammation or hyaluronic acid to lubricate the joint). These can temporarily relieve pain but do not stop the degeneration of cartilage. As the disease progresses, many patients ultimately require joint replacement surgery (for knees or hips) to regain mobility and pain relief. Surgery is effective but invasive, expensive, and not suitable for all patients. There is a glaring medical gap: no FDA-approved drug or biologic can slow or reverse osteoarthritis. In other words, we lack a disease-modifying osteoarthritis drug (sometimes abbreviated as a “DMOAD”). This gap represents a huge opportunity – whichever company can develop a true DMOAD will likely capture significant market share and change the standard of care for millions of patients.
Team
At the helm of Cytonics is Dr. Gaetano Scuderi, the founder and Chairman of the Board. Dr. Scuderi is an orthopedic surgeon with over two decades of clinical experience, including an appointment as a Clinical Assistant Professor at Stanford University earlier in his career. His medical expertise and firsthand experience treating patients with spine and joint problems provided the foundational vision for Cytonics. It was Dr. Scuderi’s hypothesis about A2M and joint pain that launched the company’s core technology – a testament to how intimately he understands the problem they aim to solve. Having a physician-inventor as founder is a strength: he has likely encountered the shortcomings of current OA treatments with his own patients, and that passion often drives persistent innovation. Dr. Scuderi’s continued involvement (as Chairman) ensures the company remains clinically grounded in its approach. Beyond medicine, it’s noted in his bio that he’s a 4th-degree black belt martial artist – while not directly related to business, it reflects a level of discipline and tenacity in his character.
Day-to-day operations are led by Joey Bose, the President and Chief Executive Officer. Mr. Bose has a decade of experience spanning biotechnology R&D and healthcare investment banking. This blend of science and finance experience is valuable for a CEO guiding a biotech startup. On one hand, he has the technical literacy to understand the product and R&D needs; on the other, he is adept at coordinating capital raises and communicating with investors (skills honed in investment banking). According to the company, Mr. Bose’s responsibilities include securing funding, managing the clinical trial strategy for CYT-108, protecting intellectual property through patents, and scouting for partnership or exit opportunities. Essentially, he is a bridge between the scientific team and the business stakeholders. While relatively young in terms of executive years, Mr. Bose is supported by seasoned experts around him, and so far he has successfully raised capital through new avenues like crowdfunding while keeping the clinical program moving—no small feat. It’s also worth noting that prior to Mr. Bose’s tenure, Cytonics had other experienced executives: for example, around 2020 the CEO role was held by Antonio Carvalho, a former Novartis finance VP. This indicates the company has drawn talent from big pharma in the past, and the knowledge from those individuals likely still influences strategy (even if management has since rotated).
On the scientific front, Dr. Lewis Hanna serves as Chief Scientific Officer (CSO). Dr. Hanna has been with Cytonics since as far back as 2008, giving him deep historical knowledge of the research program. He holds a PhD and has nearly three decades of experience in developing protein therapeutics, having worked at major pharmaceutical companies including Alexion, Bristol-Myers Squibb, and Johnson & Johnson’s R.W. Johnson Pharmaceutical Research Institute. His expertise in protein chemistry, purification, and the path to FDA approval is directly relevant to CYT-108, which is a recombinant protein drug. In essence, Dr. Hanna is the one steering the laboratory and manufacturing aspects – ensuring that CYT-108 can be produced at high quality and scaled up, and that all the preclinical data meets regulatory standards. His big pharma background (especially at Alexion, which is known for developing complex biologics) likely instills a rigorous approach to Cytonics’ R&D. The presence of such an experienced CSO is a major asset for a small company; it increases confidence that the technical challenges of developing CYT-108 (which involve things like protein folding and stability) are being handled by someone who has done this before successfully.
Differentiation
Cytonics distinguishes itself in the osteoarthritis field through its unique scientific approach and its head start in real-world application. The core differentiator is Cytonics’ focus on Alpha-2-Macroglobulin (A2M) as the key to treating OA. A2M is not a random experimental drug – it’s a protein naturally found in our blood that acts as a broad-spectrum protease inhibitor. In simple terms, A2M’s job in the body is to trap and neutralize destructive enzymes (proteases) that can chew up cartilage. Osteoarthritis joints often have an excess of those destructive enzymes, leading to the breakdown of cartilage over time. Cytonics’ insight was that boosting A2M in the joint could protect the cartilage from this enzyme attack, thereby addressing a root cause of arthritis progression. This is fundamentally different from standard treatments that only reduce inflammation or mask pain. Cytonics’ therapy is aimed at the disease process itself – if successful, it could be one of the first treatments to slow the worsening of arthritis, not just temporarily relieve symptoms.
Another differentiator is that Cytonics has a two-pronged solution: a diagnostic and a therapeutic. The FACT diagnostic test can identify a specific marker (a fibronectin-aggrecan complex) that indicates ongoing cartilage breakdown. This helps pinpoint patients who are actively deteriorating and thus good candidates for A2M treatment. By having a diagnostic (FACT) to pair with the therapy (APIC or CYT-108), Cytonics can potentially offer a more personalized treatment regimen – doctors could test a patient’s joint fluid, and if the marker is positive, proceed with A2M injection, knowing the patient is likely to benefit. This kind of targeted approach is rare in orthopedics; most other OA treatments are one-size-fits-all. It gives Cytonics an edge in demonstrating the value of their therapy (they can show that patients selected by the test do better, strengthening the case for insurance coverage and adoption).
In terms of current competition, no other company has an A2M-based therapy as advanced as Cytonics does. Some regenerative medicine companies have explored A2M, but Cytonics’ patents and early mover advantage put it in pole position. When comparing to Platelet-Rich Plasma (PRP), which is a somewhat adjacent competitor (since PRP also comes from blood and is injected into joints), Cytonics’ approach is more targeted. PRP is a mix of various growth factors and proteins concentrated from blood, whereas APIC specifically concentrates one key protein (A2M) to a high level. PRP’s results in clinical studies have been mixed – some patients improve, others see little difference – possibly because PRP’s composition isn’t consistent and might not always include enough of the crucial factors for OA. Cytonics took the approach of isolating what it believes is the critical factor (A2M) and maximizing it. In essence, Cytonics is delivering a higher dose of the “active ingredient” that fights OA cartilage loss, which could lead to more reliable outcomes than PRP. Additionally, CYT-108 (the recombinant version of A2M) has been engineered to be even more effective at trapping proteases than natural A2M. This bio-engineering aspect – enhancing a human protein’s function – differentiates CYT-108 from any natural blood product treatments.
Performance
Cytonics is still a clinical-stage company, which means its performance is not measured by product sales (yet) but by progress in R&D and strategic milestones. Financially, Cytonics is not profitable and does not have substantial revenue streams at this time – this is typical for a biotech focused on developing a new drug. According to the company’s SEC filings, any revenue so far has been limited and derived from one-time deals or royalties rather than recurring product sales. For instance, Cytonics licensed its FACT diagnostic technology to Synthes (J&J), and that brought in some income (including a notable $4 million investment from Synthes a decade ago). Additionally, Cytonics entered an exclusive licensing agreement with a company called Astaria Global to use the APIC system in the veterinary market (treating joint issues in horses and other animals). Under that deal, Cytonics received upfront payments (about $100,000 as of mid-2020) and earns ongoing royalties from Astaria as the veterinary product rolls out. These partnerships mean that while Cytonics doesn’t yet sell a drug, it has occasionally booked modest revenues from technology licensing.
To put numbers on it: in the first six months of 2024, Cytonics reported revenues of approximately $170,000, compared to about $182,000 in the first six months of 2023. So annual revenues are on the order of only a few hundred thousand dollars. This small income comes from the sources mentioned – largely licensing and royalty fees (the filings specifically mention royalties from APIC treatments and veterinary usage. Meanwhile, the company’s operating expenses for R&D, clinical trials, and operations are much higher – for the first half of 2024, operating costs were around $2.5 million. Thus, Cytonics runs at a significant loss, as expected. In the full year 2023, Cytonics’ net loss was about $1.95 million, which actually was an improvement from a loss of $2.84 million in 2022. The reduced loss in 2023 suggests the company managed its costs or secured more non-dilutive funding that year (possibly grants). Cytonics has indeed been helped by grant funding – it received approximately $1.8 million in research grants from the National Institutes of Health (NIH) over its history, which support the science without adding to debt or dilution.
Risk
Investing in Cytonics entails significant risks typical of early-stage biotech ventures, as well as some specific to the osteoarthritis market and the crowdfunding context. The foremost risk is clinical and regulatory risk. Cytonics’ entire value proposition hinges on the success of its drug candidate CYT-108 in clinical trials and eventual FDA approval. While the science behind A2M is promising, it is still unproven in large human studies. There is a real possibility that the upcoming Phase 2 trial could fail to show meaningful benefit to patients. Osteoarthritis is a complex disease – pain levels and progression can vary widely among individuals, making it tricky to demonstrate a clear drug effect. If the trial results show only modest improvement (or none) compared to placebo, it would be a major setback. Even worse, if any safety concerns arise (for instance, unexpected inflammatory reactions or off-target effects), development could be halted. It’s worth noting that many seemingly hopeful treatments for OA have failed in Phase 2 or 3 in the past. This includes drugs from large companies; the history of OA drug development is littered with compounds that worked in animals but not in humans. Cytonics is not immune to that risk. And unlike a tech or consumer product startup that can pivot easily, a biotech like Cytonics often has “one shot on goal” with its specific therapy – years of work and money are tied to CYT-108’s fate.
Even if Phase 2 shows positive results, regulatory risk continues through Phase 3 and the FDA review. The FDA will scrutinize safety over a larger patient population and longer term. One theoretical risk with any potent drug in joints is that altering the joint environment could have unforeseen consequences (for example, earlier anti-NGF drugs reduced pain so much that patients overused their joints and worsened their condition; something similar, while unlikely, would be a concern to watch for with pain-masking effects). The FDA may also require that CYT-108 not just improves symptoms but perhaps shows some evidence of structural benefit (like slowing joint space narrowing on X-rays) to be labeled as disease-modifying. Meeting such endpoints is challenging and could require lengthy studies. Regulatory timelines and demands could therefore extend the road to approval, meaning Cytonics might need more funding and time than anticipated, during which investors are waiting with no guarantee of success.
Bullish Outlook
Cytonics presents a compelling narrative of innovation that could dramatically improve the lives of people suffering from osteoarthritis. The company’s key strength lies in its novel approach: harnessing a natural protein (A2M) to protect joint cartilage. This approach isn’t just theoretical – it’s supported by years of research and real patient experiences. Thousands of individuals have already received Cytonics’ A2M therapy via the APIC system, often reporting significant pain relief and improved mobility. These early successes give Cytonics a head start and a form of validation that pure laboratory research can’t offer. It’s a strong proof-of-concept that the science works in practice, laying a foundation for the next step with CYT-108.
Another major strength is the size of the opportunity. Osteoarthritis is sometimes called a “$100 billion disease” when you add up direct costs, lost productivity, and so on. By targeting the root cause of OA damage, Cytonics is going after an enormous market with few effective competitors. If CYT-108 becomes the first disease-modifying OA drug, it could be a game-changer for orthopedic medicine – akin to how the first disease-modifying drugs for rheumatoid arthritis transformed care for that condition. This means the upside for success is correspondingly large, both in terms of impact (millions of patients could benefit) and financial returns (such a therapy could generate blockbuster drug revenues).
Cytonics has also shown steady progress and resilience over the years, which is a positive indicator for future execution. The company has achieved what it set out to do at various stages: it developed a diagnostic, got it licensed to a big player; it created a treatment device, got it cleared by the FDA and used by physicians; it then engineered a new drug and navigated through a Phase 1 trial successfully. Each of these milestones adds credibility. Particularly, the completion of the Phase 1 human trial for CYT-108 means the project has transitioned from a laboratory concept to something that’s been tested in people with no major safety issues – a critical de-risking event. It opens the door to move faster through Phase 2 now with confidence that the mechanism is tolerable in humans.
The support and recognition Cytonics has earned add to the positive outlook. Receiving $1.8 million in NIH grants indicates that experts in the field (who review grant applications) believe in the science and its potential. The $4 million strategic investment from J&J’s Synthes not only provided capital but also is an external validation – a giant healthcare company saw enough promise to invest and collaborate. Such partnerships often come with access to expertise and resources; for example, Synthes’ involvement likely helped in early product development and opens a channel if Cytonics ever seeks a marketing partner for orthopedic clinics. Moreover, having an elite institution like Stanford associated through multiple advisors and research collaborations lends prestige and suggests that Cytonics’ science was vetted by leading academics.
Cytonics’ business strategy also has positive elements. By addressing short-term and long-term opportunities (selling or licensing the APIC device for immediate though modest revenue, while developing CYT-108 for the big long-term payoff), the company has been resourceful. It hasn’t relied solely on future hopes; it monetized aspects of its technology along the way. This not only provided some cash flow but also stress-tested the product in real-world settings, giving them a trove of data and experience. Additionally, Cytonics’ choice to involve the crowd (via StartEngine) can be seen as a positive in building a base of champions. Hundreds of individual investors can double as advocates, spreading word about the technology to doctors and patients they know, potentially accelerating awareness and acceptance.
Bearish Outlook
Despite its promise, Cytonics faces several significant challenges and concerns that could hinder its growth or delay its success. One of the first red flags for some observers is the length of time the company has been in development versus how far it has to go. Founded in 2006, Cytonics has been pursuing this vision for roughly 19 years and is only now entering Phase 2 trials. Drug development is lengthy, but nearly two decades without reaching market can indicate hurdles or slower-than-expected progress. Some might worry that if A2M therapy was so promising, it shouldn’t have taken this long to get to mid-stage clinical trials. Of course, funding constraints and the deliberate path of validating via devices contribute to this timeline, but the long development period could imply that widespread adoption is still years away. Investors who came in early on have had to be very patient, and new investors will also need to be patient; this is not a quick turnaround story.
Market adoption and perception is another concern. While thousands of patients have tried APIC injections, the treatment is still not mainstream in orthopedic or rheumatology practice. If APIC is indeed beneficial, why haven’t we seen it used in every sports medicine clinic by now? The likely reasons are the lack of large-scale clinical trial data and insurance coverage. This hints at a potential issue: medical skepticism and inertia. Many doctors may be aware of APIC or A2M therapy but consider it experimental or unproven, thus not offering it to patients. Changing the standard of care in medicine is notoriously hard; it usually requires unequivocal evidence from multiple large trials and inclusion in clinical guidelines. Cytonics will need to overcome a possible reputational challenge – some might lump A2M injections with the “wild west” of unproven stem cell clinics, which have given regenerative medicine a mixed reputation. Even though Cytonics is doing rigorous trials, until those results are published and peer-reviewed, there could be a stigma to fight against. Slow adoption could occur if, even post-approval, physicians take a “wait and see” approach or insurers put up reimbursement hurdles. This would delay revenue and growth for the company.
Another set of negatives revolves around competition and technological uncertainty. While Cytonics is unique in A2M, it does face competition from all the other modalities being explored. It’s possible that by the time CYT-108 is market-ready, another new therapy could eclipse it. For instance, if a gene therapy that causes joint cells to produce their own anti-arthritis factors comes to fruition, or if a competitor finds a small molecule drug that can be taken orally to similar effect, those could reduce the need for injectable A2M. Moreover, big pharma companies like Amgen or Lilly have deep pockets and could use brute-force funding to advance a rival treatment faster if they see Cytonics nearing a breakthrough. There’s a worry that Cytonics might get outpaced by a larger entity or even that a large entity might design around Cytonics’ IP (finding a different protein or approach to neutralize cartilage-degrading enzymes). In the worst case, a competitor’s failure can also tarnish Cytonics by association – for example, if another company’s OA drug trial fails and the field loses momentum, Cytonics could struggle to attract the next round of capital or interest, as investors might become pessimistic on anyone solving OA.
Financial overhang is a concern. Cytonics will require substantial money beyond the current raise to reach commercialization. There is a risk that the company could become financially over-leveraged or dilutive to existing shareholders. By the time a product is approved, early crowdfunding investors might find their ownership percentage significantly diluted by subsequent venture capital rounds or strategic investments needed to finance Phase 3 trials and marketing. If these later investors negotiate preferences (like multiple liquidation preferences or guaranteed returns), they could soak up a disproportionate amount of the exit value, leaving common shareholders (including the crowdfunders) with a smaller slice of the pie. Essentially, even if Cytonics succeeds, the structure of its financing could affect how much of that success flows back to the current investors. Since current investors are buying common stock (last in line), this is a real consideration.
Executive Summary
Cytonics is a clinical-stage biotech company on a mission to transform how we treat osteoarthritis, a degenerative joint disease that afflicts tens of millions of people. Founded by an orthopedic surgeon, the company is grounded in the idea that the body’s own biochemistry holds the key to healing arthritic joints. Cytonics’ proprietary solution centers on Alpha-2-Macroglobulin (A2M), a naturally occurring protein that can inhibit the enzymes which degrade cartilage in osteoarthritis. By boosting A2M in diseased joints – initially through a patient’s own blood concentrate (the APIC system) and soon via a lab-made injectable drug (CYT-108) – Cytonics aims to not just ease the pain of OA but halt its progression. In a field where current treatments only provide temporary relief, this approach could be revolutionary, offering hope for patients to maintain mobility without resorting to surgery.
The company’s journey has been marked by steady scientific progress and real-world validation of its concept. It has secured multiple patents, treated thousands of patients with its first-generation A2M therapy, and attracted funding and partnerships from credible sources like the NIH and Johnson & Johnson’s Synthes. Now, Cytonics stands at a pivotal juncture: it has completed initial human trials and is raising growth capital on the StartEngine platform to fund Phase 2 trials of CYT-108. This crowdfunded offering allows everyday investors to own a piece of a biotech that could capture a share of the multi-billion dollar osteoarthritis market if successful. At the offering valuation (around $65 million pre-money), investors are betting that Cytonics can multiply in value by delivering a genuinely disease-modifying osteoarthritis treatment – a holy grail in orthopedics.
However, along with this opportunity come substantial risks. Biotechnology development is inherently high-risk, and Cytonics is no exception. The company must navigate clinical trials and regulatory approval, and positive early signs must translate into statistically robust results in larger patient groups. The road to an FDA-approved product will be expensive and could encounter setbacks, meaning additional financing (and dilution) is likely. Even with approval, Cytonics would face the challenge of convincing physicians and insurers to adopt a new therapy in place of familiar, if inadequate, remedies. Competition from pharmaceutical giants and other startups is ongoing, and there is no guarantee Cytonics will emerge on top.
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Company Funding & Growth
Funding history
- Total Prior Capital Raised
- $34,200,000
- Grants
- $1,800,000
- VC Backed?
- Yes
Close Date | Platform | Valuation | Total Raised | Security Type | Status | Reg Type |
---|---|---|---|---|---|---|
03/14/2026 | StartEngine | $104,080,000 | $2,461,864 | Equity - Common | Active | RegA+ |
08/25/2024 | StartEngine | $66,557,294 | $938,436 | Equity - Preferred | Funded | RegCF |
05/28/2024 | StartEngine | $65,792,080 | $3,626,034 | Equity - Preferred | Funded | RegCF |
03/31/2023 | DealMaker Securities | $58,915,995 | $1,695,868 | Equity - Preferred | Funded | RegCF |
10/14/2022 | SeedInvest | $58,915,996 | $2,633,766 | Equity - Preferred | Funded | RegCF / RegD 506(c) |
04/30/2021 | SeedInvest | $46,701,000 | $4,667,638 | Equity - Preferred | Funded | RegA+ |
05/18/2019 | SeedInvest | $32,400,000 | $494,344 | Convertible Note | Funded | RegCF / RegD 506(c) |
Growth Charts
Revenue History
Note: Revenue data points reflect the latest of either the most recent fiscal year's financials, or updated revenues directly from the founder, at each raise's close date.
Valuation History
Price per Share History
Note: Share prices shown in earlier rounds may not be indicative of any stock splits.