About this raise
Neurocarrus, with a valuation of $11.25 million, is raising funds on Wefunder. The company has developed the drug candidate N-001 to provide neuron-specific pain relief without risk of addiction. Neurocarrus’ N-001 is a first-in-class, long-acting aesthetic-like drug that could reduce or avoid opioid use and targets neurons to calm their excessive activity that causes pain. The company is led by an experienced team and has patents issued on exclusively licensed technology in the US and other countries. Paul Blum founded Neurocarrus in October 2017. The current crowdfunding campaign has a minimum target of $50,000 and a maximum target of $124,000. The campaign proceeds will be used for salaries, contract research organisation services for pre-clinical development, consultants for FDA review, manufacturing, and operations.
Investment Overview
Committed $142,814 :
Deal Terms
Company & Team
Company
- Year Founded
- 2017
- Industry
- Healthcare & Pharmaceuticals
- Tech Sector
- Distribution Model
- B2B2C
- Margin
- High
- Capital Intensity
- High
Financials
- Revenue -29.5% YoY
-
$136,909
as of FY2024
-
Cash on Hand
-
$50,000
as of FY2024
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Synopsis
Neurocarrus is a biotech company specializing in the development of non-addictive pain relief solutions. The company has created a drug candidate, N-001, designed to provide neuron-specific pain relief without the risk of addiction. Neurocarrus aims to address the widespread issue of pain management, particularly for individuals who suffer from severe pain due to inflammation or surgery. The company's primary customers are likely to include healthcare providers, pain management clinics, and pharmaceutical companies seeking alternatives to opioid-based pain relief options.
The problem Neurocarrus addresses is the significant challenge of managing severe pain without the risk of addiction. Traditional pain relief methods, such as opioid medications, carry a high risk of addiction and other systemic side effects, making them a less-than-ideal solution for long-term pain management. This has led to a pressing need for safer, more effective pain relief options that do not compromise patient health or lead to dependency.
Neurocarrus' solution is N-001, a first-in-class, long-acting drug that targets neurons to calm excessive activity causing pain. Unlike opioids, N-001 cannot enter the brain, thereby eliminating the risk of addiction. The drug provides pain relief comparable to prescription pain medications without causing side effects on muscles or balance. By focusing on neuron-specific action, N-001 offers a safer alternative for patients requiring effective pain management.
Price
Neurocarrus is raising funds through a SAFE (Simple Agreement for Future Equity) with a valuation cap of $11.25 million. This type of security allows investors to convert their investment into equity at a future date, typically during the next priced funding round, at a valuation not exceeding the cap. There is no discount associated with this SAFE, which means investors will convert their investment at the valuation cap or the next round's valuation, whichever is lower.
The exit potential for startups in the healthcare and pharmaceuticals sector, particularly those focusing on novel drug technologies, can be significant. For Neurocarrus to provide a 10X return to investors, the company would need to achieve an exit valuation of approximately $112.5 million (not accounting for dilution). Achieving this level of return typically requires successful clinical trials, regulatory approvals, and market adoption of their drug candidate, N-001. Additionally, forming strategic partnerships or securing acquisition offers from larger pharmaceutical companies could also drive higher valuations.
Assuming Neurocarrus reaches an exit valuation of $112.5 million, investors would see a 10X return on their investment before accounting for any dilution. This scenario hinges on the company's ability to navigate the complex regulatory landscape, demonstrate the efficacy and safety of N-001 through clinical trials, and effectively commercialize the product.
In terms of revenue multiples, companies in the biotech and pharmaceutical industries often see high multiples due to the potential for significant revenue growth once a drug is approved and commercialized. Additionally, a valuation of $11.25M is on the lower end of biotech valuations typically seen in the online startup markets.
Investors should consider the inherent risks associated with early-stage biotech companies, including the lengthy and costly process of drug development and regulatory approval. However, the potential for high returns exists if Neurocarrus successfully brings its non-addictive pain relief solution to market and captures a significant share of the pain management drugs market.
Market
The US pain management drugs market, which Neurocarrus targets with its drug candidate N-001, is substantial, valued at approximately $308.6 billion. This market is growing at an annual rate of 3.46%, driven by several key market drivers and trends.
Market drivers include the increasing prevalence of chronic pain conditions, heightened awareness of the risks associated with opioid addiction, and the growing demand for non-addictive pain management solutions. Chronic pain affects a significant portion of the population, and the need for effective pain relief options is acute. The opioid crisis has also led to a shift in both regulatory and consumer preferences towards safer, non-addictive alternatives, creating a favorable environment for Neurocarrus' N-001.
Trends impacting this market include advancements in biotechnology and targeted drug delivery systems, which are enabling the development of more effective and safer pain management solutions. Additionally, there is a growing emphasis on personalized medicine, where treatments are tailored to individual patient needs. These trends can positively impact Neurocarrus by aligning with its focus on neuron-specific pain relief that minimizes systemic side effects and addiction risks.
While Neurocarrus operates in a highly competitive market with numerous established players, its focus on creating a neuron-specific drug that cannot enter the brain and therefore avoids addiction sets it apart from traditional pain relief options. This unique approach can help Neurocarrus carve out a significant niche within the broader pain management market.
Team
Neurocarrus is led by CEO Paul Blum, who brings over 25 years of experience in cell engineering and microbiology as a professor at the University of Nebrasca and UC-Santa Cruz. He is joined by Derek Allen (Research Scientist) who holds a PhD in Microbiology from University of Nebraska-Lincoln. The company has board members with deep experience at major biopharma institutions like Cleveland Clinic, American Academy of Pain Medicine and Smith, Gambrell & Russell (intellectual property law).
The skills and experience of the key team members align well with Neurocarrus' goals of developing and commercializing a non-addictive pain relief drug. Blum's industry experience and managerial skills are crucial for navigating the complex regulatory landscape and securing the necessary approvals for N-001. The advisors' expertise in drug development and regulatory affairs further enhances the team's ability to achieve these objectives.
However, there are potential gaps in the team that could be critical for achieving the company's future milestones. For instance, additional expertise in areas such as clinical trial management, large-scale manufacturing, and marketing could be beneficial as Neurocarrus moves closer to commercialization. Expanding the team to include professionals with these skills could help ensure that the company is well-prepared to bring N-001 to market and achieve its long-term goals.
Differentiation
Neurocarrus differentiates itself in the highly competitive pain management market through its unique approach to non-addictive pain relief. The company's drug candidate, N-001, stands out by targeting neurons specifically to calm excessive activity causing pain, without entering the brain and thus avoiding addiction risks. This approach is in contrast to traditional pain relief methods, such as opioids, which carry a high risk of addiction and systemic side effects.
In terms of industry competitors, Neurocarrus faces competition from well-established pharmaceutical companies such as Purdue Pharma and Johnson & Johnson. Purdue Pharma, known for its opioid pain medications like OxyContin, has faced significant legal challenges and public backlash due to the opioid crisis. Johnson & Johnson offers a range of pain management products, including both over-the-counter and prescription medications. Compared to these larger competitors, Neurocarrus is a smaller company focused on a niche segment of the market with its non-addictive, neuron-specific approach.
Another competitor is Collegium Pharmaceutical, which develops and commercializes pain medications with a focus on abuse-deterrent formulations. Collegium's products, like Xtampza ER, are designed to provide effective pain relief while minimizing the potential for abuse. While Collegium's approach addresses the abuse potential of opioids, Neurocarrus' N-001 aims to eliminate the risk of addiction altogether by not entering the brain.
Neurocarrus' target customer demographics include healthcare providers, pain management clinics, and patients seeking non-addictive pain relief options. Within this broad market, the company is likely to appeal particularly to individuals with chronic pain conditions, post-surgical patients, and those with a history of substance abuse. These demographics are increasingly seeking safer alternatives to opioids due to heightened awareness of addiction risks and the desire for effective long-term pain management solutions.
In terms of product quality, Neurocarrus has secured patents on its technology, providing intellectual property protection and a competitive edge. The company's focus on neuron-specific pain relief without systemic side effects positions it as a differentiated player in the market. Pricing details for N-001 are not yet available, but the company's unique value proposition could justify a premium pricing strategy compared to traditional pain medications, provided it demonstrates superior safety and efficacy.
Performance
Neurocarrus has shown some progress in its financial performance, although it is still in the early stages of development. The company reported annual revenue of $136,909 for the most recent fiscal year (from grants), reflecting a negative growth rate of-30% from the prior year’s revenue of $194,284. However, it is important to note that the company does not yet have paying customers, and this revenue is likely derived from other sources such as grants or early-stage funding.
The monthly burn rate for Neurocarrus is $3,566, which indicates the company's ongoing expenses. As of the most recent fiscal year end, the company had cash and cash equivalents amounting to $50,000 This figure suggests that Neurocarrus has over a year of runway. However, as the company enters clinical trials in humans, expenses will rise dramatically and the company will be reliant on external funding to continue operations.
In terms of profitability, Neurocarrus reported a net income of -$42,789 for the most recent fiscal year, compared to a net income of $6,171 in the prior fiscal year. This negative net income reflects the company's investment in research and development, as well as operational costs associated with advancing its drug candidate, N-001, through the pre-clinical phase.
Neurocarrus has also raised a total of $624,168 in prior funding rounds, along with $3.3 million in grants. These funds have been instrumental in supporting the company's development efforts. However, given the high capital intensity of pharmaceutical development, Neurocarrus will likely require additional funding to achieve its milestones.
Despite the challenges, Neurocarrus has made good progress in product development, securing patents on its technology and building a foundation for future growth. The company's ability to manage its burn rate, secure additional funding, and advance N-001 through clinical trials will be critical factors in its ongoing performance.
Risk
Investing in Neurocarrus comes with several unique risks specific to the company's stage of development and market dynamics. One of the primary risks is the extensive regulatory approval process required for new drug candidates. The journey from pre-clinical development to market approval by the FDA is both time-consuming and costly. Any setbacks or delays in this process could significantly impact the company's timeline and financial stability.
Neurocarrus is still in the pre-product phase, meaning there is inherent uncertainty regarding the efficacy and safety of its drug candidate, N-001. Although the company has patents on its technology and has completed initial animal safety studies, the lack of completed human trials adds another layer of risk.
The competitive landscape in the pain management market is another significant risk factor. With numerous established players and ongoing research into alternative pain relief solutions, Neurocarrus faces the challenge of differentiating its product and gaining market share. The company's ability to demonstrate clear advantages over existing pain relief options is critical for its success.
Another concern is the company's runway. Although Neurocarrus has raised funds in prior rounds and through grants, the high capital intensity of pharmaceutical development means that the company will likely need additional funding to sustain operations and continue product development. The current burn rate and available cash may not be sufficient to cover all future expenses, leading to potential funding gaps.
Bullish Outlook
Neurocarrus presents several key factors that contribute to a positive outlook for the company. The US pain management drugs market, valued at $308.6 billion and growing at a rate of 3.46% annually, offers significant market opportunities. The increasing prevalence of chronic pain conditions and the growing demand for non-addictive pain management solutions provide a favorable environment for Neurocarrus' drug candidate, N-001.
One of Neurocarrus' unique strengths is its neuron-specific approach to pain relief, which targets excessive activity causing pain without entering the brain and thus avoiding addiction risks. This approach sets Neurocarrus apart from traditional opioid-based pain relief options and positions the company to capture a niche segment within the broader pain management market. The company's patents on its technology further reinforce its competitive advantage and provide intellectual property protection.
In terms of growth drivers, Neurocarrus is well-positioned to leverage emerging trends in biotechnology and targeted drug delivery systems. The company's focus on neuron-specific pain relief aligns with the growing emphasis on personalized medicine and safer, more effective pain management solutions. Additionally, Neurocarrus has the potential to expand its market reach by targeting new demographics and forming strategic partnerships with healthcare providers and pharmaceutical companies.
The favorable investment terms offered through a SAFE with a valuation cap of $11.25 million provide investors with an opportunity to potentially convert their investment into equity at a future date, typically during the next priced funding round, at a valuation not exceeding the cap. This structure aligns investor interests with the company's long-term growth prospects.
Bearish Outlook
Neurocarrus faces several key factors that contribute to a bearish outlook for the company. One of the primary concerns is the extensive regulatory approval process required for new drug candidates. The journey from pre-clinical development to market approval by the FDA is both time-consuming and costly, and any setbacks or delays could significantly impact the company's timeline and financial stability.
The competitive landscape in the pain management market is another significant challenge for Neurocarrus. With numerous established players and ongoing research into alternative pain relief solutions, the company must differentiate itself and gain market share. Neurocarrus' lack of completed animal trials adds another layer of risk, as successful pre-clinical and clinical trials are essential for moving forward. Any negative outcomes could hinder progress or lead to additional costs.
Concerns about the team or leadership also contribute to a bearish outlook. While CEO Paul Blum has relevant industry experience, the company's small team and reliance on external advisors may not be sufficient to address all the challenges associated with drug development and commercialization. Additionally, potential gaps in expertise in areas such as clinical trial management and large-scale manufacturing could be critical for achieving future milestones.
Growth inhibitors for Neurocarrus include technological and regulatory hurdles, limited market adoption, and a lack of innovation compared to competitors. The company must navigate the complex and lengthy regulatory process to bring its drug candidate, N-001, to market. Market adoption may be slow due to the highly competitive landscape and the presence of established players with strong market positions. Additionally, while Neurocarrus' neuron-specific approach is unique, it must continuously innovate to stay ahead of competitors who may develop similar or more advanced solutions.
Executive Summary
Neurocarrus is a biotech company focused on developing non-addictive pain relief solutions, specifically through its drug candidate, N-001. The company targets healthcare providers, pain management clinics, and pharmaceutical companies looking for alternatives to opioid-based pain relief options.
The company is raising funds through a SAFE with a valuation cap of $11.25 million. This security type allows investors to convert their investment into equity at a future date, typically during the next priced funding round, at a valuation not exceeding the cap. Achieving a 10X return would require an exit valuation of approximately $112.5 million (not accounting for dilution), necessitating successful clinical trials, regulatory approvals, and market adoption of N-001.
The US pain management drugs market is valued at $308.6 billion, with an annual growth rate of 3.46%. Key market drivers include the increasing prevalence of chronic pain, heightened awareness of opioid addiction risks, and the demand for non-addictive pain management solutions. These trends align well with Neurocarrus' focus on developing a neuron-specific, non-addictive pain relief drug.
Neurocarrus reported annual revenue of $136,909 (from grants) for the most recent fiscal year, down -30% from 2022. The company's monthly burn rate is $3,566, and it has $50,000 in cash and cash equivalents. Despite a net income of -$42,789, Neurocarrus has raised $624,168 in prior funding rounds and $3.3 million in grants, supporting its development efforts.
Neurocarrus differentiates itself through its unique approach to non-addictive pain relief, targeting neurons specifically to calm excessive activity causing pain. Competitors such as Purdue Pharma and Johnson & Johnson offer traditional pain medications, while Collegium Pharmaceutical focuses on abuse-deterrent formulations. Neurocarrus' target customers include individuals with chronic pain, post-surgical patients, and those with a history of substance abuse.
The team is led by CEO Paul Blum, who has over 25 years of relevant industry experience. The presence of four relevant advisors further enhances the team's ability to navigate drug development and regulatory challenges. However, there are potential gaps in expertise in areas such as clinical trial management and large-scale manufacturing that could be critical for future milestones.
On the bullish side, Neurocarrus operates in a substantial and growing market with a clear need for non-addictive pain relief solutions. The company's unique approach and secured patents provide a competitive edge. Successful clinical trials and regulatory approvals could lead to significant market adoption and high returns for investors.
On the bearish side, the company is still in the pre-product phase with no paying customers and a burn rate likely to go up substantially in the coming 12 months. The regulatory approval process and competitive landscape pose significant challenges. Additionally, the high revenue multiple suggests that investors are paying a premium based on future expectations, adding to the investment risk.
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Company Funding & Growth
Funding history
- Total Prior Capital Raised
- $624,168
- Grants
- $3,321,000
- VC Backed?
- No